Jerold Chun Selected Research

Sphingosine-1-Phosphate Receptors

1/2022	The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis.
1/2022	Ponesimod inhibits astrocyte-mediated neuroinflammation and protects against cingulum demyelination via S1P1 -selective modulation.
1/2022	Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
10/2021	Deletion of Sphingosine 1-Phosphate receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis.
2/2021	Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects.
1/2021	Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke.
11/2019	Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
1/2018	Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia.
1/2017	Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.
1/2017	Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.

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Jerold Chun Research Topics

Disease

24	Multiple Sclerosis 01/2022 - 01/2006
15	Inflammation (Inflammations) 12/2022 - 04/2008
15	Fibrosis (Cirrhosis) 04/2022 - 01/2007
14	Neuralgia (Stump Neuralgia) 01/2022 - 07/2004
11	Aneuploidy (Aneuploid) 01/2021 - 11/2003
9	Neoplasms (Cancer) 01/2015 - 04/2004
7	Demyelinating Diseases (Demyelinating Disease) 01/2022 - 07/2004
7	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2021 - 02/2011
6	Pain (Aches) 01/2022 - 08/2006
5	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 02/2015
5	Myocardial Ischemia (Ischemic Heart Diseases) 01/2017 - 09/2006
5	Reperfusion Injury 01/2016 - 09/2006
4	Hyperalgesia 12/2018 - 07/2004
4	Atherosclerosis 01/2017 - 08/2008
4	Lung Injury 12/2013 - 01/2008
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2013 - 01/2008
3	Body Weight (Weight, Body) 01/2022 - 03/2009
3	Down Syndrome (Down's Syndrome) 11/2021 - 02/2015
3	Carcinogenesis 01/2018 - 05/2009
3	Hypertrophy 01/2017 - 01/2016
3	Infarction (Infarctions) 01/2017 - 09/2006
3	Hypoxia (Hypoxemia) 01/2012 - 11/2010
2	Thrombosis (Thrombus) 01/2022 - 11/2019
2	Atrophy 01/2022 - 06/2009
2	Arthritis (Polyarthritis) 01/2022 - 08/2013
2	Chronic Progressive Multiple Sclerosis 01/2022 - 01/2022
2	Sepsis (Septicemia) 01/2022 - 04/2008
2	Neuroinflammatory Diseases 01/2022 - 04/2021
2	Brain Diseases (Brain Disorder) 06/2021 - 01/2021
2	Ischemic Stroke 01/2021 - 01/2015
2	Hemorrhage 11/2019 - 09/2011
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2019 - 07/2015
2	Ureteral Obstruction 01/2017 - 12/2007
2	Ischemia 01/2017 - 02/2007
2	Bone Resorption 10/2014 - 03/2014
2	Idiopathic Pulmonary Fibrosis 12/2013 - 01/2008
2	Asthma (Bronchial Asthma) 10/2013 - 11/2009
2	Pneumonia (Pneumonitis) 10/2013 - 10/2011
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2011 - 01/2010
2	Pathologic Processes 04/2010 - 12/2002
2	Autoimmune Diseases of the Nervous System 03/2010 - 08/2004
2	Peripheral Nerve Injuries 08/2006 - 07/2004
2	Ovarian Neoplasms (Ovarian Cancer) 03/2005 - 02/2004
2	Neuroblastoma 06/2002 - 04/2002
1	Fatigue 01/2022
1	Rheumatoid Arthritis 01/2022
1	Disease Susceptibility (Diathesis) 01/2022
1	Disease Progression 01/2022

Drug/Important Bio-Agent (IBA)

39	Lysophosphatidic Acid ReceptorsIBA 01/2022 - 07/2004
35	lysophosphatidic acidIBA 01/2022 - 06/2002
27	Sphingosine-1-Phosphate ReceptorsIBA 01/2022 - 04/2004
19	Fingolimod Hydrochloride (FTY720)FDA Link 01/2022 - 08/2004
15	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2022 - 09/2006
13	LipidsIBA 01/2022 - 12/2002
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2004
8	Pharmaceutical PreparationsIBA 01/2022 - 01/2006
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2008
5	Biological ProductsIBA 01/2021 - 09/2006
5	Amyloid (Amyloid Fibrils)IBA 01/2020 - 02/2015
5	Bleomycin (Blenoxane)FDA LinkGeneric 12/2013 - 01/2008
5	LysophospholipidsIBA 07/2011 - 06/2002
4	CytokinesIBA 04/2022 - 06/2005
4	Phospholipids (Phosphatides)FDA LinkGeneric 10/2011 - 04/2004
3	SphingolipidsIBA 12/2022 - 09/2006
3	siponimodIBA 01/2022 - 02/2021
3	CollagenIBA 01/2022 - 05/2013
3	RNA (Ribonucleic Acid)IBA 01/2022 - 11/2021
3	NucleotidesIBA 01/2021 - 11/2003
3	EnzymesIBA 12/2018 - 02/2008
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017 - 09/2011
3	alkylglycerophosphoethanolamine phosphodiesteraseIBA 01/2012 - 04/2004
3	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA 10/2011 - 04/2004
3	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 11/2010 - 04/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2007 - 05/2004
2	ponesimodIBA 01/2022 - 02/2021
2	Protein Isoforms (Isoforms)IBA 11/2021 - 07/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 04/2021 - 10/2013
2	Retroelements (Retrotransposon)IBA 01/2021 - 04/2013
2	sphingosine kinaseIBA 11/2019 - 02/2010
2	oxidized low density lipoproteinIBA 01/2017 - 05/2011
2	Complement System Proteins (Complement)IBA 04/2013 - 04/2008
2	Myelin-Associated GlycoproteinIBA 11/2010 - 05/2010
2	Myelin ProteinsIBA 05/2010 - 08/2004
2	GTP-Binding Proteins (G-Protein)IBA 02/2010 - 11/2009
2	HDL LipoproteinsIBA 08/2008 - 09/2006
2	Transforming Growth Factor beta (TGF-beta)IBA 12/2007 - 01/2007
1	Adenine FDA LinkGeneric 04/2022
1	Fibronectins (Fibronectin)IBA 01/2022
1	Fibrinogen (Factor I)FDA Link 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	EndotoxinsIBA 01/2022
1	Small Cytoplasmic RNAIBA 01/2022
1	CuprizoneIBA 01/2022
1	Small Nuclear RNA (snRNA)IBA 01/2022
1	U 0126 (UO 126)IBA 01/2022

Therapy/Procedure

15	Therapeutics 01/2022 - 04/2004
3	Ligation 01/2020 - 05/2012
3	Spinal Injections 06/2013 - 11/2009
2	Transplantation 01/2011 - 01/2007
2	Kidney Transplantation 02/2006 - 01/2006